MYOP-PATH

Portrait of Caroline Klaver, scientific coordinator of MYOP-PATH

Prof. Caroline C.W. Klaver

Scientific Coordinator of MYOP-PATH, based at Erasmus University Medical Centre in Rotterdam, the Netherlands

Research field

Eye Disease, Genetic Epidemiology

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Research Profile

Who?

“My affection for genetics started in biology class at high school. I enjoyed calculating how many different shades of pea would arise from crossing a green and a yellow pea. This fascination never faded”, said Professor Caroline Klaver in her inaugural lecture. She is an expert in the genetics of eye disorders.

Why?

“Near-sightedness is a growing public health issue due to its rapidly rising prevalence. High myopia confers a risk of blindness for which there are no therapeutic options. The causes of near-sightedness are complex and largely unknown. A better understanding is required for prevention and treatment”.

What?

“MYOP-PATH aims to unravel the disease pathways of myopia (near-sightedness). We recently identified many genetic variants associated with myopia. Now, we will investigate how the genes interact with the environment to create near-sightedness. Our hope is that this knowledge will create starting points for high myopia therapy.”

How?

"With around 250,000 study participants, this will be the largest myopia study performed so far. We will use the latest technological advances to 1) identify new myopia genes, 2) develop a model to estimate a person's risk for high myopia and 3) study the effect of genes on eye function in mice and zebrafish."

Deciphering the genetic background of near-sightedness

In the Picture
In the Picture
Image credits

Background image: MYOP-PATH

Portrait of the project coordinator: MYOP-PATH

Timeline (in chronological order): 2010: Daniel Novta on Flickr Creative Commons, 2013 (crowd): James Cridland, 2013 (myopia simulation): National Eye Institute, National Institutes of Health