2 months 3 weeks ago Help us improve our website: http://t.co/vY9vRzmYRH! Please take our visitor survey: http://t.co/8gY0wRZtGx. Thank you...
2 months 3 weeks ago 1st European Research Forum on Healthy Ageing: 03 Sept in Bxl. Policy makers, scientists, industrials: save the date! http://t.co/6TXrBI5rdt
3 months 5 days ago Gender inequalities in health: a matter of policies according to @sophieproject http://t.co/TzwZzXko3g
4 months 2 days ago 1/3 of cancer patients killed by 'fat-burning' process termed cachexia, @CNIO_Cancer researchers say http://t.co/GjfipsdG2R
5 months 4 hours ago New EU research project @pneumonp aims to tackle antibiotic resistance via inhalable nano therapeutics #nanomedicine http://t.co/VQN9WHojG2
5 months 2 weeks ago Urban renewal improves the health of neighbours in Barcelona according to EU-funded project @sophieproject http://t.co/F0mKCdPBZ5
5 months 3 weeks ago Check this article on #CommHERE: how to spread the word about research and reach out beyond the scientific community http://t.co/VDcKVDEfcc
6 months 2 weeks ago Scientists @CNIO_Cancer among the 40 most important global researchers http://t.co/Rc0hIsq6dN
6 months 4 weeks ago 2nd workshop @CIBER_ISCIII to strengthen the EU‐LAC Health Research Cooperation http://t.co/93qLQObcQj
8 months 2 weeks ago The European Symposium in Drug Synthesis @unisiena will take place on May 18-23. You can register until April 15!! http://t.co/V8kxQIev9S

HOMAGE

Prof. Faiez Zannad

Scientific Coordinator of HOMAGE, based at the Institut National de la Santé et de la Recherche Médicale (Inserm), CHU Nancy, University of Lorraine, France

Research field

Heart Failure, Clinical Trials, Biomarkers

If you like this

If you want to know more

Who?

Faiez Zannad is Professor of Therapeutics and Cardiology in France. “For many years, my focus was on the treatment of heart failure. My interest has now shifted to prevention. We have a chance to stop the disease 10 to 20 years earlier if we can accurately identify a patient at risk at an early stage", says Professor Zannad.

Why?

Heart failure affects more than 3.5 million people in Europe every year. It is the major cause of death and the most frequent cause of hospitalisation for patients over 65 years old. The prevalence of heart diseases is rising because the population is ageing. Therefore, we need methods to prevent or delay heart failure.

What?

“We aim to validate biomarkers for heart failure.” Biomarkers are small molecules present in body fluids that reflect the disease state. A biomarker profile will identify patients at high risk before the onset of symptoms. “We also want to use the biomarkers to predict which patients will respond to specific therapies.”

How?

“We will validate biomarkers which have already been identified and need to be confirmed on a larger scale”, says Prof. Zannad. This is a collaboration of partners from nine European countries and the USA. Combining the datasets will speed up the translation of results into tests that can be applied in clinical practice.

Validating biomarkers for heart failure

Blood sample collected from a French study participant

Clinical Investigation Centre (CIC) Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Plasma samples that will be used to measure biomarkers

Clinical Investigation Centre (CIC) Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Serum and plasma stored in liquid nitrogen at - 200 °C

Biobank of the CIC Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Biobank at CIC Inserm-CHU Nancy (A biobank is a type of repository that stores biological samples for use in research.)

Image credit: Inserm / P. Delapierre

Blood cell samples stored in the biobank

CIC Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Ultrasound of the carotid artery, which supplies the head and neck with oxygenated blood

CIC Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Echocardiography is an essential element of the collection of measures for the IMAGE database

Institut Lorrain du Cœur et des Vaisseaux Louis Mathieu, CIC Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

Data-management is an essential part of processing millions of data for statistical analysis

CIC Inserm-CHU Nancy. Image credit: Inserm / P. Delapierre

‹ ›

HOMAGE project European Society of Cardiology Institut National de la Santé et de la Recherche Médicale (Inserm)

PDF version

Background image: HOMAGE

Portrait of the project coordinator: HOMAGE

Timeline (in chronological order): 1999-mineralocorticoid receptor antagonists: Inserm / M. Depardieu; 1999-beta blockers: Fotolia; 2000: Inserm / P. Latron; 2012: Inserm / M. Depardieu