HUMAN

Portrait of Associate Professor Knut Steffensen, Scientific Coordinator of HUMAN

Dr Knut R. Steffensen

Scientific Coordinator of HUMAN, based at Karolinska Institutet, Sweden

Research field

Healthy Ageing

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Research Profile

Who?

“Interaction between multidisciplinary researchers creates an inspiring scientific environment. It stimulates creative discussions. Thus coordinating a large European research network is highly rewarding”, says Dr Steffensen. He is a group leader at the Department of Laboratory Medicine at Karolinska Institutet in Sweden.

Why?

The European population is growing older. As a result, the number of patients with metabolic disorders is rising dramatically. We know that genes play a role in the development of metabolic diseases. A complete understanding of the disease mechanisms is required to prevent and to treat these diseases.

What?

HUMAN studies the function of genetic risk factors for metabolic disorders such as diabetes and cardiovascular disease. Dr Steffensen explains: “We will generate mice with liver and pancreatic beta cells originating from human donor stem cells. This enables us to study the gene functions in human-derived organs.”

How?

The complexity of metabolic disorders and healthy ageing can only be tackled by large interdisciplinary research networks. The HUMAN consortium brings together outstanding basic research institutes and leading European biotech companies. They are setting up a powerful platform to investigate and understand healthy ageing.

Uncovering the genetic mechanism behind healthy ageing

In the Picture
In the Picture
Image credits

Background image: Paolo Garagnani

Portrait of the project coordinator: HUMAN project

Timeline (in chronological order): 1860s: Wikimedia; 1900s: Paolo Garagnani; 1953: Antony Barrington Brown; 1963: National Digestive Diseases Information Clearinghouse; 2006: National Institutes of Health; 2010: HUMAN project; 2013: HUMAN project