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MYOAGE

Portrait of Prof. Gillian Butler-Browne, Coordinator of the European health research project MYOAGE

Prof. Gillian Butler-Browne

Scientific Coordinator of MYOAGE, based at the Institut National de la Santé et de la Recherche Médicale (Inserm), Paris, France

Research field

Sarcopenia (age-related muscle loss)

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Research Profile

Who?

“My work combines my two passions: cooking and research. That is to say, I am trying to find the recipe for healthy ageing”, says Gillian Butler-Browne, Research Director of the Inserm unit 'therapy for striated muscle'. “My team studies the molecular mechanisms and cellular compartments that enable human muscles to regenerate.”

Why?

Progressive muscle weakness (sarcopenia) is a major component of muscle ageing, increasing elderly frailty and dependence. For instance, many elderly people have an inadequate muscle regeneration and become bed-ridden after a hip fracture. MYOAGE aims to counteract the loss of mobility and independence of the elderly population.

What?

In the elderly, muscles become weaker, more susceptible to damage and they recover more slowly. This leads to a disease state known as ‘sarcopenia’. MYOAGE will address various aspects of muscle loss and weakness: 1) responsible molecular mechanisms and pathways, 2) the physiology and 3) preventive therapeutic strategies.

How?

MYOAGE represents a consortium of European clinicians and researchers gathering knowledge on various aspects of muscle ageing. A cohort of elderly people was created to support the research on biological and physiological aspects of age-related muscle weakness, allowing MYOAGE to provide a unique overview on its mechanisms.

Understanding and combating age-related muscle weakness

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In the Picture
Image credits

Background image: MYOAGE

Portrait of the project coordinator: MYOAGE

Timeline (in chronological order): 1961: Inserm / P. Latron; 1998: Inserm / P. Delapierre; 2005: Inserm / P. Latron