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CLEAR

portrait of Prof. Andrea Ballabio

Prof. Andrea Ballabio

Scientific Coordinator of CLEAR, based at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples, Italy

Research field

Biotechnology, Lysosomal Storage Disorders

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Research Profile

Who?

"I wanted to become a paediatrician because I love children. Working as a paediatrician, I became increasingly interested in the fundamental aspects of genetic diseases. This is why I made the shift from practising as a medical doctor to doing more research work", says Prof. Ballabio, Director of TIGEM in Naples.

Why?

Cellular clearance seems to play a very important role in life processes such as ageing. If the CLEAR network does not work properly, toxic substances accumulate in the cell. This can cause lysosomal storage disorders that, in certain cases, could lead to neurodegenerative diseases.

What?

CLEAR is the name of a gene network that was recently discovered at TIGEM. CLEAR controls cellular clearance, ensuring waste is removed from our body cells. The aim of the project is to thoroughly understand how the CLEAR network functions. In addition, we will develop strategies to modulate cellular clearance.

How?

Close collaboration between physicians and scientists from different disciplines and different countries is required to develop methods to manipulate the CLEAR network in diseases. A combination of genomics, bioinformatics, systems biology, chemical genomics, cell biology and mouse genetics approaches will be used.

Finding the key to human ageing and neurodegenerative diseases

In the Picture
In the Picture
CLEAR project website PDF versionPDF version
Image credits

Background image: CLEAR

Portrait of the project coordinator: CLEAR

Timeline (in chronological order): 1881-1882: M.L. Cohen, Flickr Creative Commons; 1950s-60s: Erin Hass, Flickr Creative Commons; 1963: Jens Florian, Wikimedia Commons