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DEEP
Prof. Adriana Ceci
Scientific Coordinator of DEEP, based at the University Aldo Moro, Bari, Italy
Research field
Medicines for Children
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Who?
Adriana Ceci is an Associate Professor of Paediatrics and a member of the Paediatric Committee of the European Medicines Agency. She is enthusiastic when she talks about the DEEP project: “I’m very satisfied that the development of medicines for children is finally recognised as a fundamental issue at the European level.”
Why?
Worldwide, about 60,000 children are born with thalassemia every year. Frequent blood transfusions can ensure adequate oxygen carrying capacity in patients. However, the transfusions result in an accumulation of iron in the body. Deferiprone can remove the excess iron, but the correct dosage for children is uncertain.
What?
DEEP aims to determine the correct doses of deferiprone in children of different ages. Deferiprone is prescribed to patients with thalassemia, a severe inherited form of anaemia. The proper use of deferiprone in children is a challenge because, like most drugs, it has only been tested on adults in clinical trials.
How?
DEEP is a multi-national network of researchers that face the complex task of conducting clinical trials in children. The European collaboration allows us to share our expertise. Our major challenge is the development of protocols in accordance with ethical and methodological standards and international recommendations.
Developing drugs for children: children are not small adults
DEEP pays particular attention to developing tools to inform children about the research project they are being asked to participate in
DEEP clinical trial materials
Keeping children involved in the trials is fundamental for the success of the project
DEEP project website GRIP - Global research in Paediatrics TEDDY – Task-force in Europe for Drug Development for the Young NEOMERO - European multicenter network to evaluate pharmacokinetics, safety and efficacy of Meropenem in neonatal sepsis and meningitis ARPEC - Antibiotic Resistance and Prescribing in European Children TINN - Treat Infections in NeoNates TINN2 - Treat Infections in NeoNates 2 TIF – Thalassaemia International Federation EMA - European Medicines Agency In Focus article 'The gift of life'In Focus article 'That's health folks!'PDF version
Background image: DEEP
Portrait of the project coordinator: DEEP
Timeline (in chronological order): DEEP
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